Translational Pathway of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Enhancing Efficacy by Increasing Bioavailability & Improving Pharmacokinetics
Time: 10:00 am
day: Day One
Details:
- Outlining how to increase aqueous solubility: C-terminal amide substitution
- Increasing resistance to proteolysis: Alanine scan and D-amino acid substitution
- Reviewing how to increase membrane permeability: N-terminal myristoylation
